N6-adenosine-methyltransferase 70 kDa subunit (METTL3) is an enzyme that in humans is encoded by the METTL3 gene.[5] METTL3 is located on the human chromosome 14q11.2 (Cancer Biology) and out of the METTL protein family, it is the most studied. [6]
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the post-transcriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine (m6A).[5] METTL3 forms the m6 a methyltransferase complex with METTL14 and WTP and is responsible for a majority of the m6a modifications of mRNA.[6] The most common modification being the catalyzation of m6a with the methyltransferase complex.[7] METTL3 is expressed in a variety of normal tissues, such as the lymphoid, testis, prostate and fallopian tube tissues. The enzyme is also responsible for mechanisms related to tumor development, RNA stability and maturation, and has suggested roles in ensuring animal survival.[6]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000165819 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022160 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: METTL3 methyltransferase like 3".
- ^ a b c Qi YN, Liu Z, Hong LL, Li P, Ling ZQ (August 2023). "Methyltransferase-like proteins in cancer biology and potential therapeutic targeting". Journal of Hematology & Oncology. 16 (1): 89. doi:10.1186/s13045-023-01477-7. PMC 10394802. PMID 37533128.
- ^ Xu P, Ge R (February 2022). "Roles and drug development of METTL3 (methyltransferase-like 3) in anti-tumor therapy". European Journal of Medicinal Chemistry. 230: 114118. doi:10.1016/j.ejmech.2022.114118. PMID 35063732.