Machuca is a Spanish and Portuguese surname.[1] Notable people with the surname include:
- Alexis Machuca (born 1990), Argentine footballer
- Anggello Machuca (born 1984), Paraguayan footballer
- Edgar Machuca (born 1989), Paraguayan footballer
- Juan Machuca (born 1951), Chilean footballer
- Manuel Machuca (1924–1985), Chilean footballer
- Pedro Machuca (c. 1490–1550), Spanish architect
- Santiago Machuca (born 1929), Puerto Rican sport shooter