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Madin-Darby canine kidney (MDCK) cells are a model mammalian cell line used in biomedical research. MDCK cells are used for a wide variety of cell biology studies including cell polarity, cell-cell adhesions (termed adherens junctions), collective cell motility, toxicity studies,[1] as well as responses to growth factors. It is one of few cell culture models that is suited for 3D cell culture and multicellular rearrangements known as branching morphogenesis.[2]
- ^ Lindsay CD (November 1996). "Assessment of aspects of the toxicity of Clostridium perfringens epsilon-toxin using the MDCK cell line". Human & Experimental Toxicology. 15 (11): 904–908. doi:10.1177/096032719601501107. PMID 8938486. S2CID 21968438.
- ^ O'Brien LE, Zegers MM, Mostov KE (July 2002). "Opinion: Building epithelial architecture: insights from three-dimensional culture models". Nature Reviews. Molecular Cell Biology. 3 (7): 531–537. doi:10.1038/nrm859. PMID 12094219. S2CID 13410353.