Margatoxin

Scorpion short toxin
Margatoxin. Disulphide bonds are highlighted. PDB 1mtx [1]
Identifiers
SymbolToxin_2
PfamPF00451
Pfam clanCL0054
InterProIPR001947
PROSITEPDOC00875
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Margatoxin (MgTX) is a peptide that selectively inhibits Kv1.3 voltage-dependent potassium channels. It is found in the venom of Centruroides margaritatus, also known as the Central American Bark Scorpion. Margatoxin was first discovered in 1993. It was purified from scorpion venom and its amino acid sequence was determined.

  1. ^ Johnson BA, Stevens SP, Williamson JM (December 1994). "Determination of the three-dimensional structure of margatoxin by 1H, 13C, 15N triple-resonance nuclear magnetic resonance spectroscopy". Biochemistry. 33 (50): 15061–70. doi:10.1021/bi00254a015. PMID 7999764.

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