In organic chemistry, the Murai reaction is an organic reaction that uses C-H activation to create a new C-C bond between a terminal or strained internal alkene and an aromatic compound using a ruthenium catalyst.[1] The reaction, named after Shinji Murai, was first reported in 1993. While not the first example of C-H activation, the Murai reaction is notable for its high efficiency and scope.[2][3] Previous examples of such hydroarylations required more forcing conditions and narrow scope.[4][1]
- ^ a b Kakiuchi, Fumitoshi; Kochi, Takuya (2008-10-01). "Transition-Metal-Catalyzed Carbon-Carbon Bond Formation via Carbon-Hydrogen Bond Cleavage". Synthesis. 2008 (19): 3013–3039. doi:10.1055/s-2008-1067256. ISSN 0039-7881.
- ^ Murai, Shinji; Kakiuchi, Fumitoshi; Sekine, Shinya; Tanaka, Yasuo; Kamatani, Asayuki; Sonoda, Motohiro; Chatani, Naoto (1993-12-09). "Efficient catalytic addition of aromatic carbon-hydrogen bonds to olefins". Nature. 366 (6455): 529–531. Bibcode:1993Natur.366..529M. doi:10.1038/366529a0.
- ^ Murai, S.; Kakiuchi, F.; Sekine, S.; Tanaka, Y.; Kamatani, Asayuki; Sonoda, M.; Chatani, Naoto (1994-01-01). "Catalytic C-H/olefin coupling". Pure and Applied Chemistry. 66 (7): 1527–1534. doi:10.1351/pac199466071527. ISSN 1365-3075.
- ^ Murai, Shinji; Chatani, Naoto; Kakiuchi, Fumitoshi (1997-03-01). "Catalytic addition of C-H bonds to multiple bonds with the aid of ruthenium complexes". Catalysis Surveys from Asia. 1 (1): 35–51. doi:10.1023/A:1019064627386. ISSN 1384-6574.