Nepenthe is a fictional medicine for sorrow.
Nepenthe may also refer to:
- USS Nepenthe (SP-112), a luxury yacht belonging to James Deering
- Nepenthe Productions, the production company of Martin Rosen
- Nepenthe (restaurant), a restaurant in Big Sur, California
- Nepenthe (video game), a hand-drawn role-playing video game
- Nepenthes, a genus of carnivorous plants
- Nepenthes (sculpture), a series of four sculptures by artist Dan Corson
- "Nepenthe" (Star Trek: Picard), an episode of Star Trek: Picard