Nephrogenic diabetes insipidus

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Nephrogenic diabetes insipidus
Other names	arginine vasopressin resistance; AVP-R; renal diabetes insipidus
Specialty	Nephrology, endocrinology, urology
Symptoms	Polyuria, nocturia, and polydipsia.
Complications	Dehydration, seizures
Diagnostic method	Urine tests, blood tests, fluid deprivation test
Differential diagnosis	AVP-D (central), Diabetes mellitus
Treatment	Drinking sufficient fluids
Medication	thiazides, aspirin
Frequency	3 per 100,000 per year

Nephrogenic diabetes insipidus, recently renamed arginine vasopressin resistance (AVP-R) and previously known as renal diabetes insipidus, is a form of diabetes insipidus primarily due to pathology of the kidney. This is in contrast to central or neurogenic diabetes insipidus, which is caused by insufficient levels of vasopressin (also called antidiuretic hormone, ADH). Nephrogenic diabetes insipidus is caused by an improper response of the kidney to vasopressin, leading to a decrease in the ability of the kidney to concentrate the urine by removing free water.