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Neurokinin A

TAC1 tachykinin, precursor 1
Solution structure of the tachykinin peptide Neurokinin A in the presence of micelles.[1]
Identifiers
SymbolTAC1
Alt. symbolsTAC2, NKNA
NCBI gene6863
HGNC11517
OMIM162320
RefSeqNM_013998
UniProtP20366
Other data
LocusChr. 7 q21-q22
Search for
StructuresSwiss-model
DomainsInterPro
Neurokinin A
Identifiers
3D model (JSmol)
ChemSpider
MeSH Neurokinin+A
UNII
  • InChI=1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)/t28-,31+,32+,33+,34+,35+,36+,37+,40+,41+/m1/s1 ☒N
    Key: HEAUFJZALFKPBA-JPQUDPSNSA-N ☒N
  • InChI=1/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)/t28-,31+,32+,33+,34+,35+,36+,37+,40+,41+/m1/s1
    Key: HEAUFJZALFKPBA-JPQUDPSNBV
  • C[C@H]([C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cnc[nH]2)N)O
Properties
C50H80N14O14S
Molar mass 1133.32
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.[2] Neurokinin A has many excitatory effects on mammalian nervous systems and is also influential on the mammalian inflammatory and pain responses.[3]

  1. ^ PDB: 1N6T​; Chandrashekar IR, Cowsik SM (December 2003). "Three-dimensional structure of the mammalian tachykinin peptide neurokinin A bound to lipid micelles". Biophys. J. 85 (6): 4002–11. Bibcode:2003BpJ....85.4002C. doi:10.1016/S0006-3495(03)74814-0. PMC 1303701. PMID 14645089.
  2. ^ Cite error: The named reference n4 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference n23 was invoked but never defined (see the help page).
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