Non-Homologous Isofunctional Enzymes (NISE) are two evolutionarily unrelated enzymes that catalyze the same chemical reaction. Enzymes that catalyze the same reaction are sometimes referred to as analogous as opposed to homologous (Homology (biology)), however it is more appropriate to name them as Non-homologous Isofunctional Enzymes, hence the acronym (NISE).[1] These enzymes all serve the same end function but do so in different organisms without detectable similarity in primary and possibly tertiary structures.[2]
- ^ Omelchenko, Marina V.; Galperin, Michael Y.; Wolf, Yuri I.; Koonin, Eugene V. (2010). "Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution". Biology Direct. 5: 31. doi:10.1186/1745-6150-5-31. PMC 2876114. PMID 20433725.
- ^ Gomes, Monete Rajão; Guimarães, Ana Carolina Ramos; De Miranda, Antonio Basílio (2011). "Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for Tritryps". Enzyme Research. 2011: 1–8. doi:10.4061/2011/543912. PMC 3145330. PMID 21808726.