Back ARN missatger amb nucleòsids modificats Catalan Nukleosid-modifizierte mRNA German ARN mensajero con nucleósidos modificados Spanish RNA Duta dengan nukleosida yang termodifikasi ID ヌクレオシド修飾メッセンジャーRNA Japanese Nucleoside-gemodificeerd mRNA Dutch เอ็มอาร์เอ็นเอที่ดัดแปลงนิวคลีโอไซด์ Thai RNA thông tin biến đổi nucleoside Vietnamese
A nucleoside-modified messenger RNA (modRNA) is a synthetic messenger RNA (mRNA) in which some nucleosides are replaced by other naturally modified nucleosides or by synthetic nucleoside analogues.[1] modRNA is used to induce the production of a desired protein in certain cells. An important application is the development of mRNA vaccines, of which the first authorized were COVID-19 vaccines (such as Comirnaty and Spikevax).
- ^ Chien KR, Zangi L, Lui KO (October 2014). "Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine". Cold Spring Harbor Perspectives in Medicine. 5 (1): a014035. doi:10.1101/cshperspect.a014035. PMC 4292072. PMID 25301935.