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P6, P-6, or P.6 may refer to:
- P6 (microarchitecture), a sixth-generation Intel x86 microprocessor microarchitecture
- POWER6, a sixth-generational IBM microprocessor microarchitecture
- p6 protein, a protein of HIV
- HAT-P-6, a star in the constellation Andromeda
- Integrated Truss Structure#P6, S6 trusses, trusses on the International Space Station
- Rover P6 series, a saloon car model produced from 1963 to 1977 in Solihull, West Midlands, England
- SIG Sauer P225/P6, a variant of the P225 pistol used by West German police forces
- Pentacon Six, a single-lens reflex (SLR) medium format camera system
- Period 6, a period of the periodic table of elements
- Primavera P6, a project management software package by Primavera (software)
- IATA code for Privilege Style, a charter airline
- Principle 6 campaign, opposing anti-gay Russian laws at the 2014 Olympics
- P6 ATAV, an Indonesian light attack vehicle
- P-6, a variant of the Cold War era Soviet naval cruise missile SS-N-3A Shaddock
- PPPPPP (manga), a short hand for the manga by Maporo 3-Gō.
- Netpbm File_formats, binary ppm file
- Joint Primary 6 Examination, a standardized examination from 1949 to 1962