PRDX4

PRDX4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PN8, 3TJB, 3TJF, 3TJG, 3TJJ, 3TJK, 3TKP, 3TKQ, 3TKR, 3TKS, 4RQX
Identifiers
Aliases	PRDX4, AOE37-2, AOE372, HEL-S-97n, PRX-4, peroxiredoxin 4
External IDs	OMIM: 300927; MGI: 1859815; HomoloGene: 4672; GeneCards: PRDX4; OMA:PRDX4 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	23,686,397 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	154,123,750 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; tibia; ; islet of Langerhans; ; parotid gland; ; stromal cell of endometrium; ; beta cell; ; gonad; ; right testis; ; left testis; ; cartilage tissue;
	Top expressed in
	saccule; ; otic placode; ; otic vesicle; ; external carotid artery; ; dermis; ; endocardial cushion; ; maxillary prominence; ; Gonadal ridge; ; vas deferens; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; peroxidase activity; thioredoxin peroxidase activity; antioxidant activity; protein binding; peroxiredoxin activity; oxidoreductase activity;
Cellular component	cytoplasm; cytosol; smooth endoplasmic reticulum; endoplasmic reticulum; mitochondrion; extracellular exosome; nucleus; extracellular space; secretory granule lumen; ficolin-1-rich granule lumen; extracellular region;
Biological process	male gonad development; 4-hydroxyproline metabolic process; extracellular matrix organization; I-kappaB phosphorylation; protein maturation by protein folding; cell redox homeostasis; reactive oxygen species metabolic process; spermatogenesis; negative regulation of male germ cell proliferation; cellular oxidant detoxification; neutrophil degranulation; response to oxidative stress; hydrogen peroxide catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10549
	53381
	ENSG00000123131
	ENSMUSG00000025289
	Q13162
	O08807
	NM_006406
	NM_016764; NM_001313711
	NP_006397
	NP_001300640; NP_058044
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxiredoxin-4 is a protein that in humans is encoded by the PRDX4 gene.^[5]^[6] It is a member of the peroxiredoxin family of antioxidant enzymes.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123131 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025289 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jin DY, Chae HZ, Rhee SG, Jeang KT (Jan 1998). "Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation". J. Biol. Chem. 272 (49): 30952–61. doi:10.1074/jbc.272.49.30952. PMID 9388242.
^ "Entrez Gene: PRDX4 peroxiredoxin 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123131 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025289 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9388242-5] Jin DY, Chae HZ, Rhee SG, Jeang KT (Jan 1998). "Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation". J. Biol. Chem. 272 (49): 30952–61. doi:10.1074/jbc.272.49.30952. PMID 9388242.

[entrez-6] "Entrez Gene: PRDX4 peroxiredoxin 4".

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PRDX4

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