Papyrus Oxyrhynchus 5101, designated by 2227 (in the Alfred Rahlfs numbering of koine Greek Septuagint manuscripts), or P.Oxy.77 (LXXVII) 5101, is a manuscript of the Greek Septuagint Psalms (an ancient translation of the Hebrew Bible Psalms), written on papyrus in roll form. It has survived in a very fragmentary condition. Using the study of comparative writings styles (palaeography), it has been dated to the middle of the first - middle of the second century CE.
P.Oxy.77 5101 uses the Tetragrammaton (name of God in the Hebrew Bible) written in palaeo-Hebrew script instead of substituting it with the Greek title κύριος (kyrios / Lord), and is currently the earliest extant copy of the Septuagint Psalms.