Back بودوفيلوتوكسين Arabic Podofillotoksin Azerbaijani Podoffylotocsin Welsh Podophyllotoxin German Podofilotoxina Spanish پودوفیلوتوکسین Persian Podofyllotoksiini Finnish Podophyllotoxine French Podofillotossina Italian ポドフィロトキシン Japanese
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| Clinical data | |
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| Trade names | Condylox,[1] Wartec, others |
| Other names | (5R,5aR,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d] [1,3]dioxol-6(5aH)-one |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a684055 |
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| ATC code | |
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| Pharmacokinetic data | |
| Elimination half-life | 1.0 to 4.5 hours. |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.007.502 |
| Chemical and physical data | |
| Formula | C22H22O8 |
| Molar mass | 414.410 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 183.3 to 184 °C (361.9 to 363.2 °F) |
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Podophyllotoxin (PPT) is the active ingredient in Podofilox, a medical cream used to treat genital warts and molluscum contagiosum.[2] It is not recommended for HPV infections without external warts.[2] It can be applied either by a healthcare provider or the patient themselves.[2]
Podophyllotoxin is a non-alkaloid lignin extracted from the roots and rhizomes of plants of the genus Podophyllum.[3] A less refined form known as podophyllum resin is also available, but has greater side effects.[4][5]
Podophyllotoxin was first isolated in pure form in 1880 by Valerian Podwyssotzki (1818 – 28 January 1892), a Polish-Russian privatdozent at the University of Dorpat (now Tartu, Estonia) and assistant at the Pharmacological Institute there.[6][7][8]
PPT is on the World Health Organization's List of Essential Medicines.[9]
- ^ "What is Condylox?" (in German). Retrieved 2018-08-15.
- ^ a b c "Podofilox". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
- ^ Xu H, Lv M, Tian X (2009). "A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007". Current Medicinal Chemistry. 16 (3): 327–49. doi:10.2174/092986709787002682. PMID 19149581.
- ^ "Podophyllum Resin". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
- ^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 307. hdl:10665/44053. ISBN 9789241547659.
- ^ See:
- Podwyssotzki V (1880). "Pharmakologische Studien über Podophyllum peltatum" [Pharmacological studies of Podophyllum peltatum]. Archiv für experimentelle Pathologie und Pharmakologie (in German). 13 (1–2): 29–52. doi:10.1007/BF01833268. S2CID 33803976. Podwyssotzki named podophyllotoxin on p. 30: " … ich nenne sie bis auf weiteres Podophyllotoxin." ( … for the time being I call it "podophyllotoxin".)
- Podwyssotzki V (10 September 1881). "The active constituents of podophyllotoxin". Pharmaceutical Journal and Transactions. 3rd series. 12: 217–219.
- Podwyssotzki V (March 1882). "On the active constituents of podophyllin". American Journal of Pharmacy. 54: 102–115.
- Podwyssotzki V (1882). "Über die wirksamen Bestandtheile des Podophyllins" [On the active components of podophyllin]. Berichte der Deutschen Chemischen Gesellschaft (in German). 15: 377–378.
- Obituary: Kobert R (February 1893). "Valerian Podwyssotzki". Bulletin of Pharmacy. 7 (2): 49–52.
- ^ Cragg GM, Kingston DG, Newman DJ (2011). Anticancer Agents from Natural Products, Second Edition (2 ed.). CRC Press. p. 97. ISBN 9781439813836.
- ^ Shah Z, Gohar UF, Jamshed I, Mushtaq A, Mukhtar H, Zia-Ui-Haq M, et al. (April 2021). "Podophyllotoxin: History, Recent Advances and Future Prospects". Biomolecules. 11 (4): 603. doi:10.3390/biom11040603. PMC 8073934. PMID 33921719.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.