Protective isolation or reverse isolation denotes the practices used for protecting vulnerable persons for contracting an infection.[1] When people with weakened immune systems are exposed to organisms, it could lead to infection and serious complications.[2][3] It is sometimes practiced in patients with severe burns and leukemia, or those undergoing chemotherapy.[4][5] When reverse isolation is practiced in laminar air flow or high-efficiency particulate air (HEPA)-filtered rooms, there was an improvement in survival for patients receiving bone marrow or stem cell grafts.[6]