Resident Evil 4 is a 2005 a video game.
RE4 or RE 4 may also refer to:
- Resident Evil 4 (2023 video game), a remake to the above game
- Resident Evil: Afterlife, the fourth film in the live action series
- Resident Evil: Death Island, the fourth film in the animated series
- the Wupper-Express (RE 4), a rail service in Germany
- the RegioExpress route RE4, a rail service in Switzerland
- RE4, a chassis code for Honda CR-V (third generation)
- (10594) 1996 RE4, a minor planet
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