STAT4

STAT4
Identifiers
Aliases	STAT4, SLEB11, signal transducer and activator of transcription 4
External IDs	OMIM: 600558; MGI: 103062; HomoloGene: 20679; GeneCards: STAT4; OMA:STAT4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	191,151,596 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	52,146,348 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; sperm; ; middle temporal gyrus; ; blood; ; right auricle; ; cardiac muscle tissue of right atrium; ; left testis; ; right testis; ; Pituitary Gland; ; right frontal lobe;
	Top expressed in
	spermatid; ; seminiferous tubule; ; granulocyte; ; spermatocyte; ; mesenteric lymph nodes; ; blood; ; zygote; ; spleen; ; primary oocyte; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; DNA-binding transcription factor activity; DNA binding; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytosol;
Biological process	transcription, DNA-templated; regulation of transcription, DNA-templated; receptor signaling pathway via JAK-STAT; signal transduction; positive regulation of transcription by RNA polymerase II; interleukin-12-mediated signaling pathway; cytokine-mediated signaling pathway; interleukin-21-mediated signaling pathway; interleukin-23-mediated signaling pathway; interleukin-35-mediated signaling pathway; defense response; regulation of cell population proliferation; response to peptide hormone;
	Sources:Amigo / QuickGO
Orthologs
	6775
	20849
	ENSG00000138378
	ENSMUSG00000062939
	Q14765
	P42228
	NM_001243835; NM_003151
	NM_011487; NM_001308266
	NP_001230764; NP_003142
	NP_001295195; NP_035617
	Wikidata
View/Edit Human	View/Edit Mouse

Signal transducer and activator of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6.^[5] STAT proteins are key activators of gene transcription which bind to DNA in response to cytokine gradient.^[6] STAT proteins are a common part of Janus kinase (JAK)- signalling pathways, activated by cytokines.STAT4 is required for the development of Th1 cells from naive CD4+ T cells^[7] and IFN-γ production in response to IL-12.^[8] There are two known STAT4 transcripts, STAT4α and STAT4β, differing in the levels of interferon-gamma (IFN-γ )production downstream.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138378 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062939 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamamoto K, Quelle FW, Thierfelder WE, Kreider BL, Gilbert DJ, Jenkins NA, et al. (July 1994). "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation". Molecular and Cellular Biology. 14 (7): 4342–9. doi:10.1128/mcb.14.7.4342. PMC 358805. PMID 8007943.
^ Darnell JE, Kerr IM, Stark GR (June 1994). "Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins". Science. 264 (5164): 1415–21. Bibcode:1994Sci...264.1415D. doi:10.1126/science.8197455. PMID 8197455.
^ Kaplan MH (2005). "STAT4: a critical regulator of inflammation in vivo". Immunologic Research. 31 (3): 231–42. doi:10.1385/IR:31:3:231. PMID 15888914.
^ Bacon CM, Petricoin EF, Ortaldo JR, Rees RC, Larner AC, Johnston JA, O'Shea JJ (August 1995). "Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 92 (16): 7307–11. Bibcode:1995PNAS...92.7307B. doi:10.1073/pnas.92.16.7307. PMC 41328. PMID 7638186.
^ Hoey T, Zhang S, Schmidt N, Yu Q, Ramchandani S, Xu X, et al. (August 2003). "Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses". The EMBO Journal. 22 (16): 4237–48. doi:10.1093/emboj/cdg393. PMC 175783. PMID 12912921.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138378 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062939 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[1_Yamamoto_1994-5] Yamamoto K, Quelle FW, Thierfelder WE, Kreider BL, Gilbert DJ, Jenkins NA, et al. (July 1994). "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation". Molecular and Cellular Biology. 14 (7): 4342–9. doi:10.1128/mcb.14.7.4342. PMC 358805. PMID 8007943.

[6] Darnell JE, Kerr IM, Stark GR (June 1994). "Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins". Science. 264 (5164): 1415–21. Bibcode:1994Sci...264.1415D. doi:10.1126/science.8197455. PMID 8197455.

[2_Kaplan_2005-7] Kaplan MH (2005). "STAT4: a critical regulator of inflammation in vivo". Immunologic Research. 31 (3): 231–42. doi:10.1385/IR:31:3:231. PMID 15888914.

[3_Bacon_1995-8] Bacon CM, Petricoin EF, Ortaldo JR, Rees RC, Larner AC, Johnston JA, O'Shea JJ (August 1995). "Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 92 (16): 7307–11. Bibcode:1995PNAS...92.7307B. doi:10.1073/pnas.92.16.7307. PMC 41328. PMID 7638186.

[9] Hoey T, Zhang S, Schmidt N, Yu Q, Ramchandani S, Xu X, et al. (August 2003). "Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses". The EMBO Journal. 22 (16): 4237–48. doi:10.1093/emboj/cdg393. PMC 175783. PMID 12912921.

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STAT4

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