Santa Cruz de Abranes (Santa Cruz d'Abranes in the vernacular Leonese language) is a Spanish village in the municipality of Pedralba de la Pradería (Zamora, Castile and León) and is situated on the Spanish-Portuguese border.
The village belonged to Portugal until the eighteenth century, and it now belongs to the comarca of Senabria. The village is located within the protected natural space of Sierra de la Culebra.