Santino is an Italian masculine given name or nickname, meaning “little saint” in Italian. It is a diminutive version of the given name Santo, meaning “saint” or “holy”. Notable people with the name include:
- Santino Andino (born 2005), Argentine footballer
- Santino Basaldella (born 2004), Argentine surfer
- Santino Ferrucci (born 1998), American race car driver
- Santino Fontana (born 1982), American actor
- Santino Garsi (1542–1604), Italian lutenist and composer
- Santino Marella (born 1974), ring name of WWE wrestler Anthony Carelli
- Santino Quaranta (born 1984), American soccer player
- Santino Rice (born 1974), American fashion designer
- Santino Solari (1576–1646), Swiss architect
- Santino Vera (born 2006), Argentine footballer
- Santino William Legan, American perpetrator of the Gilroy Garlic Festival shooting