Signal transducing adaptor molecule

STAM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L0A, 3F1I, 3LDZ
Identifiers
Aliases	STAM, STAM-1, STAM1, Signal transducing adaptor molecule
External IDs	OMIM: 601899; MGI: 1329014; HomoloGene: 37788; GeneCards: STAM; OMA:STAM - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	17,716,824 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	14,154,445 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; amniotic fluid; ; endothelial cell; ; retinal pigment epithelium; ; corpus callosum; ; Brodmann area 23; ; pars compacta; ; germinal epithelium; ; Pons; ; ganglionic eminence;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ganglionic eminence; ; perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; superior frontal gyrus; ; medial ganglionic eminence; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin-like protein ligase binding;
Cellular component	cytoplasm; cytosol; endosome; early endosome membrane; membrane; ESCRT-0 complex;
Biological process	negative regulation of epidermal growth factor receptor signaling pathway; regulation of extracellular exosome assembly; multivesicular body assembly; endosomal transport; protein transport; positive regulation of exosomal secretion; intracellular protein transport; signal transduction; positive regulation of signal transduction; macroautophagy; protein deubiquitination; membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	8027
	20844
	ENSG00000136738
	ENSMUSG00000026718
	Q92783
	P70297
NM_003473; NM_001324282; NM_001324283; NM_001324284; NM_001324285;
	NM_001324286; NM_001324287; NM_001324288; NM_001324289
	NM_011484; NM_001356337
NP_001311211; NP_001311212; NP_001311213; NP_001311214; NP_001311215;
	NP_001311216; NP_001311217; NP_001311218; NP_003464
	NP_035614; NP_001343266
	Wikidata
View/Edit Human	View/Edit Mouse

Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136738 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026718 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K (August 1996). "Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM". Biochemical and Biophysical Research Communications. 225 (3): 1035–9. doi:10.1006/bbrc.1996.1290. PMID 8780729.
^ "Entrez Gene: STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136738 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026718 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8780729-5] Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K (August 1996). "Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM". Biochemical and Biophysical Research Communications. 225 (3): 1035–9. doi:10.1006/bbrc.1996.1290. PMID 8780729.

[entrez-6] "Entrez Gene: STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1".

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Signal transducing adaptor molecule

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