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Subgranular zone

The subgranular zone (in rat brain). (A) Regions of the dentate gyrus: the hilus, subgranular zone (sgz), granule cell layer (GCL), and molecular layer (ML). Cells were stained for doublecortin (DCX), a protein expressed by neuronal precursor cells and immature neurons. (B) Closeup of subgranular zone, located between the hilus and GCL. From a paper by Charlotte A. Oomen, et al., 2009.

The subgranular zone (SGZ) is a layer of cells in the dentate gyrus, in the hippocampal formation, which is a site of adult neurogenesis in the brain.[1]

The other major site of adult neurogenesis in the brain is the subventricular zone.[2]

  1. ^ Tuncdemir, SN; Lacefield, CO; Hen, R (18 November 2019). "Contributions of adult neurogenesis to dentate gyrus network activity and computations". Behavioural Brain Research. 374: 112112. doi:10.1016/j.bbr.2019.112112. PMC 6724741. PMID 31377252.
  2. ^ Ohira, Koji (2023). "Cortical adult neurogenesis and its biological implication". Clinical and Experimental Neuroimmunology. 14: 44–51. doi:10.1111/cen3.12652. ISSN 1759-1961. S2CID 236282146.
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