The First Men in the Moon is a novel by H. G. Wells.
The First Men in the Moon may also refer to:
- A Trip to the Moon, a silent adaptation of the novel and Jules Verne's From the Earth to the Moon
- The First Men in the Moon (1919 film), silent adaptation of the novel
- First Men in the Moon (1964 film), film adaptation of the novel
- The First Men in the Moon (2010 film), television adaptation of the novel