Thiopurine methyltransferase

TPMT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BZG, 2H11
Identifiers
Aliases	TPMT, entrez:7172, TPMTD, thiopurine S-methyltransferase
External IDs	OMIM: 187680; MGI: 98812; HomoloGene: 313; GeneCards: TPMT; OMA:TPMT - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	18,155,077 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	47,198,213 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; tendon of biceps brachii; ; rectum; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; internal globus pallidus; ; mucosa of transverse colon; ; right lobe of liver; ; mucosa of ileum; ; human kidney;
	Top expressed in
	right kidney; ; proximal tubule; ; human kidney; ; left lobe of liver; ; zygote; ; primary oocyte; ; secondary oocyte; ; transitional epithelium of urinary bladder; ; tail of embryo; ; otic vesicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	S-adenosylmethionine-dependent methyltransferase activity; transferase activity; methyltransferase activity; thiopurine S-methyltransferase activity; S-adenosyl-L-methionine binding;
Cellular component	cytosol; cytoplasm;
Biological process	nucleobase-containing compound metabolic process; methylation;
	Sources:Amigo / QuickGO
Orthologs
	7172
	22017
	ENSG00000137364
	ENSMUSG00000021376
	P51580
	O55060
	NM_000367; NM_001346817; NM_001346818
	NM_016785
	NP_000358; NP_001333746; NP_001333747
	NP_058065
	Wikidata
View/Edit Human	View/Edit Mouse

Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. A pseudogene for this locus is located on chromosome 18q.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137364 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021376 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TPMT thiopurine S-methyltransferase". National Center for Biotechnology Information. Retrieved 2012-07-02.
^ Lee D, Szumlanski C, Houtman J, Honchel R, Rojas K, Overhauser J, Wieben ED, Weinshilboum RM (March 1995). "Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1". Drug Metab. Dispos. 23 (3): 398–405. PMID 7628307.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137364 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021376 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TPMT thiopurine S-methyltransferase". National Center for Biotechnology Information. Retrieved 2012-07-02.

[pmid7628307-6] Lee D, Szumlanski C, Houtman J, Honchel R, Rojas K, Overhauser J, Wieben ED, Weinshilboum RM (March 1995). "Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1". Drug Metab. Dispos. 23 (3): 398–405. PMID 7628307.

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Thiopurine methyltransferase

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