Back U.S. Route 52 French U.S. Route 52 Portuguese U.S. Route 52 SIMPLE U.S. Route 52 Swedish 52号美国国道 Chinese
 U.S. Route 52 | ||||||||||
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 US 52 highlighted in red | ||||||||||
| Route information | ||||||||||
| Length | 2,072 mi[citation needed] (3,335 km) | |||||||||
| Existed | 1926[1]–present | |||||||||
| Major junctions | ||||||||||
| West end |  Highway 39 at the Canadian border in Portal, ND | |||||||||
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| East end | Line Street in Charleston, SC | |||||||||
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| Country | United States | |||||||||
| States | North Dakota, Minnesota, Iowa, Illinois, Indiana, Ohio, West Virginia, Kentucky, Virginia, North Carolina, South Carolina | |||||||||
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U.S. Route 52 (US 52) is a major U.S. Highway in the Central United States that extends from the northern to southeastern region of the United States. Contrary to most other even-numbered U.S. Highways, US 52 primarily follows a northwest–southeast route, and it is signed north–south or east–west depending on the local orientation of the route. The highway's northwestern terminus is in Portal, North Dakota, at the Canadian border, where it continues as Saskatchewan Highway 39. Its southeastern terminus is in Charleston, South Carolina, at Number 2 Meeting Street and White Point Garden along the Charleston Harbor.
- ^ Bureau of Public Roads & American Association of State Highway Officials (November 11, 1926). United States System of Highways Adopted for Uniform Marking by the American Association of State Highway Officials (Map). 1:7,000,000. Washington, DC: United States Geological Survey. OCLC 32889555. Retrieved March 25, 2018 – via Wikimedia Commons.