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 | This article may be too technical for most readers to understand. (October 2022) |
An upstream open reading frame (uORF) is an open reading frame (ORF) within the 5' untranslated region (5'UTR) of an mRNA. uORFs can regulate eukaryotic gene expression.[1][2] Translation of the uORF typically inhibits downstream expression of the primary ORF. However, in some genes such as yeast GCN4, translation of specific uORFs may increase translation of the main ORF.[3]
- ^ Vilela C, McCarthy JE (August 2003). "Regulation of fungal gene expression via short open reading frames in the mRNA 5'untranslated region". Molecular Microbiology. 49 (4): 859–67. doi:10.1046/j.1365-2958.2003.03622.x. PMID 12890013.
- ^ Lovett PS, Rogers EJ (June 1996). "Ribosome regulation by the nascent peptide". Microbiological Reviews. 60 (2): 366–85. doi:10.1128/MMBR.60.2.366-385.1996. PMC 239448. PMID 8801438.
- ^ Hinnebusch, Alan G. (1997-08-29). "Translational Regulation of Yeast GCN4: A window on factors that control initiator-tRNA binding to the ribosome *". Journal of Biological Chemistry. 272 (35): 21661–21664. doi:10.1074/jbc.272.35.21661. ISSN 0021-9258. PMID 9268289.