If the uterus and ovaries are to remain intact, vaginectomy will leave a canal and opening suitable for draining menstrual discharge. Otherwise, as in genital nullification, a hysterectomy must be performed to avoid the danger of retaining menstrual discharge within the body.[7] In the latter case, thorough removal of vaginal lining is necessary to avoid continued secretion within the body.[8]
In addition to vaginectomy in humans, there have been instances of vaginectomy in other animals to treat vaginal cancer.[9]
^Frey JD, Poudrier G, Chiodo MV, Hazen A (March 2017). "An Update on Genital Reconstruction Options for the Female-to-Male Transgender Patient: A Review of the Literature". Plastic and Reconstructive Surgery. 139 (3): 728–737. doi:10.1097/PRS.0000000000003062. PMID28234856.
^Walton AB, Hellstrom WJ, Garcia MM (October 2021). "Options for Masculinizing Genital Gender Affirming Surgery: A Critical Review of the Literature and Perspectives for Future Directions". Sexual Medicine Reviews. 9 (4): 605–618. doi:10.1016/j.sxmr.2021.07.002. PMID34493480. S2CID237440377.
^Bizic M, Stojanovic B, Bencic M, Bordás N, Djordjevic M (November 2020). "Overview on metoidioplasty: variants of the technique". International Journal of Impotence Research. 33 (7): 762–770. doi:10.1038/s41443-020-00346-y. PMID32826970. S2CID221217936.