Villa d'Este may be:
- Villa d'Este, a 16th-century villa in Tivoli, near Rome, Italy
- Villa d'Este (Cernobbio), a Renaissance patrician residence in Cernobbio on the shores of Lake Como, northern Italy, now a deluxe hotel
- Villa d'Este (Johannesburg), a National Heritage site in Johannesburg, Gauteng, South Africa
- Berlin Villa d'Este, a former 1920s restaurant and dance cafe in the Charlottenburg district of Berlin, Germany