YTHDC1

YTHDC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YUD, 4R3H, 4R3I
Identifiers
Aliases	YTHDC1, YT521, YT521-B, YTH domain containing 1
External IDs	OMIM: 617283; MGI: 2443713; HomoloGene: 15796; GeneCards: YTHDC1; OMA:YTHDC1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	68,350,090 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	86,984,518 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; corpus callosum; ; sural nerve; ; left ovary; ; bone marrow; ; endometrium; ; ventricular zone; ; right ovary; ; right lung; ; vagina;
	Top expressed in
	medullary collecting duct; ; conjunctival fornix; ; renal corpuscle; ; cumulus cell; ; ureter; ; ciliary body; ; pineal gland; ; vestibular membrane of cochlear duct; ; Rostral migratory stream; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding; N6-methyladenosine-containing RNA binding;
Cellular component	nucleus; nuclear speck; plasma membrane; nucleoplasm;
Biological process	mRNA processing; mRNA splice site selection; RNA splicing; regulation of mRNA splicing, via spliceosome; mRNA export from nucleus; dosage compensation by inactivation of X chromosome; posttranscriptional regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	91746
	231386
	ENSG00000275272; ENSG00000083896
	ENSMUSG00000035851
	Q96MU7
	E9Q5K9
	NM_001031732; NM_133370; NM_001330698
	NM_177680; NM_001347375; NM_001347376; NM_001359907; NM_001359908
	NP_001026902; NP_001317627; NP_588611
	NP_001334304; NP_001334305; NP_808348; NP_001346836; NP_001346837
	Wikidata
View/Edit Human	View/Edit Mouse

YTH domain-containing protein 1 is a protein that in humans is encoded by the YTHDC1 gene.^[5]^[6]^[7] YTHDC1 is a nuclear protein involved in splice site selection that localises to YT bodies; dynamic subnuclear compartments, which first appear at the beginning of S-phase in the cell cycle and disperse during mitosis.^[8]

^ ^a ^b ^c ENSG00000083896 GRCh38: Ensembl release 89: ENSG00000275272, ENSG00000083896 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035851 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stoilov P, Rafalska I, Stamm S (Oct 2002). "YTH: a new domain in nuclear proteins". Trends Biochem Sci. 27 (10): 495–7. doi:10.1016/S0968-0004(02)02189-8. PMID 12368078.
^ Hartmann AM, Nayler O, Schwaiger FW, Obermeier A, Stamm S (Dec 1999). "The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)". Mol Biol Cell. 10 (11): 3909–26. doi:10.1091/mbc.10.11.3909. PMC 25688. PMID 10564280.
^ "Entrez Gene: YTHDC1 YTH domain containing 1".
^ Nayler, O.; Hartmann, A. M.; Stamm, S. (2000-09-04). "The ER repeat protein YT521-B localizes to a novel subnuclear compartment". The Journal of Cell Biology. 150 (5): 949–962. doi:10.1083/jcb.150.5.949. ISSN 0021-9525. PMC 2175241. PMID 10973987.

[refGRCh38Ensembl-1] ENSG00000083896 GRCh38: Ensembl release 89: ENSG00000275272, ENSG00000083896 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035851 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12368078-5] Stoilov P, Rafalska I, Stamm S (Oct 2002). "YTH: a new domain in nuclear proteins". Trends Biochem Sci. 27 (10): 495–7. doi:10.1016/S0968-0004(02)02189-8. PMID 12368078.

[pmid10564280-6] Hartmann AM, Nayler O, Schwaiger FW, Obermeier A, Stamm S (Dec 1999). "The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)". Mol Biol Cell. 10 (11): 3909–26. doi:10.1091/mbc.10.11.3909. PMC 25688. PMID 10564280.

[entrez-7] "Entrez Gene: YTHDC1 YTH domain containing 1".

[8] Nayler, O.; Hartmann, A. M.; Stamm, S. (2000-09-04). "The ER repeat protein YT521-B localizes to a novel subnuclear compartment". The Journal of Cell Biology. 150 (5): 949–962. doi:10.1083/jcb.150.5.949. ISSN 0021-9525. PMC 2175241. PMID 10973987.

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YTHDC1

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