Back منطقة شبكية Arabic Zona reticular Spanish زونا رتیکولاریس Persian Zona reticularis Finnish Zona reticular Galician Zona reticular Portuguese
| Zona reticularis | |
|---|---|
 Layers of cortex. | |
| Details | |
| Identifiers | |
| Latin | zona reticularis |
| MeSH | D015385 |
| FMA | 69236 |
| Anatomical terminology | |
The zona reticularis (sometimes, reticulate zone) is the innermost layer of the adrenal cortex, lying deep to the zona fasciculata and superficial to the adrenal medulla. The cells are arranged cords that project in different directions giving a net-like appearance (L. reticulum - net).[1]
Cells in the zona reticularis produce precursor androgens including dehydroepiandrosterone (DHEA) and androstenedione from cholesterol.[2] DHEA is further converted to DHEA-sulfate via a sulfotransferase, SULT2A1.[3] These precursors are not further converted in the adrenal cortex if the cells lack 17β-Hydroxysteroid dehydrogenase. Instead, they are released into the blood stream and taken up in the testicles and ovaries to produce testosterone and the estrogens respectively.
ACTH partially regulates adrenal androgen secretion,[4] also CRH.[5][6]
In humans, the reticularis layer does contain 17α-hydroxylase; this hydroxylates pregnenolone, which is then converted to cortisol by a mixed function oxidase. Deficiency of 17α-hydroxylase results in low blood levels of estrogens, androgens, and cortisol, and the resultant compensatory increases in adrenocorticotrophic hormone stimulates the production of 11-deoxycorticosterone and corticosterone.[7] In rodents, the lack of 17α-hydroxylase results in the compensatory synthesis of corticosterone instead of cortisol.[8]
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- ^ Eroschenko, Victor P. (2008). "Figure 17.11: Adrenal (Suprarenal) Gland: Cortex and Medula". DiFiore's Atlas of Histology with Functional Correlations (11th ed.). Wolters Kluwer Health. pp. 404–5. ISBN 978-0-7817-7057-6. OCLC 173659606.
- ^ Litwack, Gerald (2022). "Figure 2.11 Pathways of biosynthesis of the principal families of human steroid hormones". Hormones (4th ed.). Academic Press. p. 41. ISBN 978-0-323-98460-7.
- ^ Rainey WE, Nakamura Y (February 2008). "Regulation of the Adrenal Androgen Biosynthesis". J. Steroid Biochem. Mol. Biol. 108 (3–5): 281–6. doi:10.1016/j.jsbmb.2007.09.015. PMC 2699571. PMID 17945481.
- ^ Pediatric Adrenal Insufficiency (Addison Disease) at eMedicine
- ^ Ibáñez L, Potau N, Marcos MV, de Zegher F (September 1999). "Corticotropin-releasing hormone as adrenal androgen secretagogue". Pediatric Research. 46 (3): 351–3. doi:10.1203/00006450-199909000-00018. PMID 10473054.
- ^ Coppola, Christopher P.; Merrell, Ronald C. (2001). "Neoplasms of the Adrenal and Endocrine Pancreas in the Elderly". In Rosenthal, Ronnie A.; Zenilman, Michael E.; Katlic, Mark R. (eds.). Principles and Practice of Geriatric Surgery. Springer. pp. 301–21. doi:10.1007/978-1-4757-3432-4_22. ISBN 978-1-4757-3432-4.
- ^ Kim SM, Rhee JH (June 2015). "A case of 17 alpha-hydroxylase deficiency". Clin Exp Reprod Med. 42 (2): 72–6. doi:10.5653/cerm.2015.42.2.72. PMC 4496435. PMID 26161337.
- ^ Nussdorfer, GG; Robba, C; Mazzochi, G; Rebuffat, P (March 1981). "Effects of angiotensin II on the zona fasciculata of the rat adrenal cortex: an ultrastructural stereologic study" (PDF). Journal of Anatomy. 132 (Pt 2): 235–42. PMC 1233369. PMID 7275800.