7-OH-DPAT

7-OH-DPAT
General
Fórmula estructural
Fórmula molecular	?
Identificadores
Número CAS	74938-11-7[1]​
ChEBI	111176
ChEMBL	CHEMBL285755
ChemSpider	1182
PubChem	1219
UNII	RR7D75YDF4
InChI InChI=InChI=1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3 Key: BLYMJBIZMIGWFK-UHFFFAOYSA-N
Propiedades físicas
Masa molar	247,193614 g/mol
[editar datos en Wikidata]

El 7-OH-DPAT ((+)7-hidroxi-N,N-di-n-[3H]propil-2-aminotetralina)^[2]​ es un compuesto químico sintético que actúa como agonista del receptor de dopamina con razonable selectividad por el subtipo de receptor D₃,^[3]​^[4]​^[5]​ y baja afinidad por los receptores de serotonina, a diferencia de su isómero estructural 8-OH- DPAT que resulta altamente selectivo por estos receptores.^[6]​^[7]​^[8]​

1. ↑ Número CAS
2. ↑ Kaichi, Yasusuke; Nonaka, Ryo-ichi; Hagino, Yoko; Watanabe, Masayuki (22 de diciembre de 1999). «Dopamine D₃ receptor binding by D₃ agonist 7-OH-DPAT (7-hydroxy-dipropylaminotetralin) and antipsychotic drugs measured ex vivo by quantitative autoradiography». Canadian Journal of Physiology and Pharmacology 78 (1): 7-11. ISSN 0008-4212. doi:10.1139/y99-104. Consultado el 16 de mayo de 2023. 
3. ↑ Mulder TB, de Vries JB, Dijkstra D, Wiechers JW, Grol CJ, Horn AS (November 1987). «Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin». Naunyn-Schmiedeberg's Archives of Pharmacology 336 (5): 494-501. PMID 2830544. doi:10.1007/bf00169305. 
4. ↑ Lévesque D, Diaz J, Pilon C, Martres MP, Giros B, Souil E, Schott D, Morgat JL, Schwartz JC, Sokoloff P (September 1992). «Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2-aminotetralin». Proceedings of the National Academy of Sciences of the United States of America 89 (17): 8155-9. Bibcode:1992PNAS...89.8155L. PMC 49875. PMID 1518841. doi:10.1073/pnas.89.17.8155. 
5. ↑ Lévesque D (August 1996). «Aminotetralin drugs and D3 receptor functions. What may partially selective D3 receptor ligands tell us about dopamine D3 receptor functions?». Biochemical Pharmacology 52 (4): 511-8. PMID 8759022. doi:10.1016/0006-2952(96)00239-0. 
6. ↑ Arvidsson LE, Johansson AM, Hacksell U, Nilsson JL, Svensson K, Hjorth S, Magnusson T, Carlsson A, Andersson B, Wikström H (November 1987). «(+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist». Journal of Medicinal Chemistry 30 (11): 2105-9. PMID 2959776. doi:10.1021/jm00394a029. 
7. ↑ Malmberg A, Nordvall G, Johansson AM, Mohell N, Hacksell U (August 1994). «Molecular basis for the binding of 2-aminotetralins to human dopamine D2A and D3 receptors». Molecular Pharmacology 46 (2): 299-312. PMID 8078492. 
8. ↑ Eltayb A, Lindblom S, Oerther S, Ahlenius S (July 2001). «Additive hypothermic effects of the 5-HT1A receptor agonist 8-OH-DPAT and the dopamine D2/3 receptor agonist 7-OH-DPAT in the rat». Acta Physiologica Scandinavica 172 (3): 205-9. PMID 11472307. doi:10.1046/j.1365-201x.2001.00858.x.