Cdk5

Quinasa dependiente de ciclina 5
Imagen del PDB basada en 1H4L.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB  Lista de códigos PDB 1H4L , 1LFR , 1UNG , 1UNH , 1UNL , 3O0G , 4AU8  Estructuras enzimáticas RCSB PDB, PDBe, PDBsum
Identificadores
Símbolos	Cdk5 (HGNC: 1774) ; LIS7; PSSALRE
Identificadores externos	OMIM: 123831 MGI: 101765 HomoloGene: 3623 ChEMBL: 4036 EBI: Cdk5 GeneCards: Gen Cdk5 UniProt: Cdk5  Bases de datos de enzimas IntEnz: entrada en IntEnz BRENDA: entrada en BRENDA ExPASy: NiceZime view KEGG: entrada en KEEG PRIAM: perfil PRIAM ExplorEnz: entrada en ExplorEnz MetaCyc: vía metabólica
Número EC	2.7.11.1
Locus	Cr. 7 q36
Ontología génica Función molecular • p53 binding • protein kinase activity • protein serine/threonine kinase activity • cyclin-dependent protein serine/threonine kinase activity • ErbB-2 class receptor binding • protein binding • ATP binding • cytoskeletal protein binding • kinase activity • protein kinase binding • acetylcholine receptor activator activity • ErbB-3 class receptor binding • ephrin receptor binding • tau-protein kinase activity Componente celular • nucleus • cytoplasm • cytosol • cytoskeleton • postsynaptic density • membrane • cyclin-dependent protein kinase 5 holoenzyme complex • lamellipodium • cell junction • filopodium • axon • dendrite • growth cone • neuromuscular junction • neuronal cell body • perikaryon • postsynaptic membrane Proceso biológico • neuron migration • synaptic transmission, dopaminergic • intracellular protein transport • nucleocytoplasmic transport • cell cycle • cell-matrix adhesión • synaptic transmission • axon guidance • synapse assembly • skeletal muscle tissue development • blood coagulation • motor neuron axon guidance • cell proliferation • visual learning • Schwann cell development • synaptic vesicle exocytosis • phosphorylation • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • sensory perception of pain • cerebellar cortex formation • hippocampus development • layer formation in cerebral cortex • central nervous system neuron development • corpus callosum development • neuron differentiation • regulation of cell migration • negative regulation of axon extension • cortical actin cytoskeleton organization • neuron projection development • negative regulation of protein ubiquitination • negative regulation of synaptic plasticity • positive regulation of protein binding • receptor catabolic process • serine phosphorylation of STAT3 protein • synaptic transmission, glutamatergic • protein localization to synapse • regulation of apoptotic process • receptor clustering • positive regulation of neuron apoptotic process • regulated secretory pathway • negative regulation of cell cycle • positive regulation of protein kinase activity • negative regulation of proteolysis • negative regulation of transcription, DNA-templated • positive regulation of calcium ion-dependent exocytosis • protein autophosphorylation • negative regulation of protein export from nucleus • behavioral response to cocaine • regulation of synaptic plasticity • synaptic vesicle endocytosis • rhythmic process • axon extension • oligodendrocyte differentiation • dendrite morphogenesis • cell division • neuron apoptotic process • excitatory postsynaptic potential • regulation of dendritic spine morphogenesis • calcium ion import • regulation of cell cycle arrest • positive regulation of protein targeting to membrane • negative regulation of neuron death • regulation of synaptic vesicle recycling • positive regulation of actin cytoskeleton reorganization • positive regulation of receptor activity Referencias: AmiGO / QuickGO
Patrón de expresión de ARNm
Más información
Ortólogos
Especies	Humano Ratón
Entrez	1020 12568
Ensembl	Véase HS Véase MM
UniProt	Q00535 P49615
RefSeq (ARNm)	NM_001164410 NM_007668
RefSeq (proteína) NCBI	NP_001157882 NP_031694
Ubicación (UCSC)	Cr. 7: 151.05 – 151.06 Mb Cr. 5: 24.42 – 24.42 Mb
PubMed (Búsqueda)	[1] [2]
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La quinasa dependiente de ciclina 5 es una enzima que en los humanos está codificado por el gen CDK5 .^[1]​^[2]​ La proteína codificada por este gen es parte de la familia de quinasa dependiente de ciclina.

1. ↑ Demetrick DJ, Zhang H, Beach DH (febrero de 1994). «Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes». Cytogenet Cell Genet 66 (1): 72-4. PMID 8275715. doi:10.1159/000133669. 
2. ↑ Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (agosto de 1992). «A family of human cdc2-related protein kinases». EMBO J 11 (8): 2909-17. PMC 556772. PMID 1639063.