CCR5

CCR5
Egitura erabilgarria PDB Ortologoaren bilaketa: PDBe RCSB PDB ID kodeen zerrenda 2L87, 2RLL, 2RRS, 2MZX, 4MBS
Identifikatzaileak
Aliasak	CCR5 (HUGO), CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22, C-C motif chemokine receptor 5 (gene/pseudogene), C-C motif chemokine receptor 5
Kanpoko IDak	OMIM: 601373   MGI: 107182   HomoloGene: 37325   GeneCards: CCR5   OMA: CCR5 - orthologs
Genetikoki lotutako gaixotasunak
type 1 diabetes mellitus 22 , human immunodeficiency virus infectious disease  [1]
Drogaren xedea
aplaviroc , cenicriviroc , Marabirok, vicriviroc , aplaviroc hydrochloride , AZD5672  [2]
Genearen kokapena (gizakia) Kromosoma: 3 (gizakia)[3] Banda 3p21.31 Hasiera 46.370.946 bp[3] Amaiera 46.376.206 bp[3]
Genearen kokapena (sagua) Kromosoma: 9 (sagua)[4] Banda 9 F4|9 75.05 cM Hasiera 123.921.580 bp[4] Amaiera 123.947.736 bp[4]
RNA adierazpen eredua Bgee gizakia sagua (ortholog) Adierazpen ohikoena epithelium of nasopharynx  parietal pleura  visceral pleura  palpebral conjunctiva  granulozito germinal epithelium  mucosa of urinary bladder  Heste sobre superficial temporal artery  jejunal mucosa  Adierazpen ohikoena lumbar subsegment of spinal cord  morula  lumbar spinal ganglion  odol enbrioi gongoil linfatiko mesenteric lymph nodes  Guruin submaxilar blastocyst  enbrioi Erreferentziazko adierazpen datu gehiago BioGPS
Gene ontologia Funtzio molekularra G proteina errezeptore akoplatuaren aktibitatea  coreceptor activity  chemokine (C-C motif) ligand 5 binding  virus receptor activity  seinaleen transdukzio aktibitatea  proteina lotura  chemokine receptor activity  C-C chemokine receptor activity  actin binding  phosphatidylinositol phospholipase C activity  C-C chemokine binding  chemokine binding  Zelularen osagaia zitoplasma  zelula-mintzaren osagai integrala  endosoma  mintza  zelula mintz  plasma-mintzaren osagai integrala  external side of plasma membrane  cell surface  Prozesu biologikoa G proteina errezeptore akoplatuaren komunikazio bidea  signaling  response to cholesterol  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  positive regulation of cytosolic calcium ion concentration  cell-cell signaling  dendritic cell chemotaxis  MAPK cascade  kimiotaxia  cellular defense response  cell surface receptor signaling pathway  erantzun immune  inflammatory response  cellular response to lipopolysaccharide  kaltzio ioi garraioa  calcium-mediated signaling  seinale transdukzio  fusion of virus membrane with host plasma membrane  chemokine-mediated signaling pathway  viral process  defense response  negative regulation of macrophage apoptotic process  cytokine-mediated signaling pathway  cell chemotaxis  Iturburuak: : Amigo / QuickGO
Ortologoak Espeziea Gizakia Sagua Entrez 1234 12774 Ensembl ENSG00000160791 ENSMUSG00000079227 UniProt P51681 P51682 RefSeq (RNAm) NM_001100168 NM_000579 NM_001394783 NM_009917 RefSeq (proteina) NP_000570 NP_001093638 NP_034047 Kokapena (UCSC) Chr 3: 46.37 – 46.38 Mb Chr 9: 123.92 – 123.95 Mb PubMed bilaketa [5] [6]
Wikidata
Ikusi/Editatu giza genea Ikusi/Editatu saguaren genea

5 motako C-C kimiokina hartzailea, CCR5 deitua, CD4 T linfozitoen eta beste zelula immunogai batzuen gainazaleko hartzailea da. R5 motako GIB birusek kohartzaile gisa erabiltzen dute zelula ostalaria infektatzeko, ezinbestez CD4 hartzailea lotzeaz gain.^[7]. Mintzeko proteina integralen kimiokina beten hartzaile-familiaren kidea da.^[8]

1. ↑ Genetikoki lotutako gaixotasunak CCR5ikusi/editatu erreferentziak Wikidatan. .
2. ↑ Fisikoki elkarreragiten duten drogak CCR5ikusi/editatu erreferentziak Wikidatan. .
3. ↑ ^{a b c} GRCh38: Ensembl release 89: ENSG00000160791 - Ensembl, May 2017
4. ↑ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000079227 – Ensembl, May 2017
5. ↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. ↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
7. ↑ Euskalterm: [Hiesa Hiztegia] [2016]
8. ↑ Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. (1996ko martxoa). «Molecular cloning and functional expression of a new human CC-chemokine receptor gene» Biochemistry 35 (11): 3362–7.  doi:10.1021/bi952950g. PMID 8639485..