Back Histamin-H4-Rezeptor German Histamine H4 receptor English Receptor de histamina H4 Spanish Recettore H4 Italian Receptor de histamina H4 Portuguese H4-гистаминовый рецептор Russian Histaminski H4 receptor Serbo-Croatian Histaminski H4 receptor Serbian HRH4 Ukrainian
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| Receptorium histamini H4 | |||||
|---|---|---|---|---|---|
| Alia | HRH4, AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R | ||||
| Fontes ext. |
OMIM: 606792 | ||||
| Locus geni (homo) | |||||
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| Chr. | Chromosoma 18 (humanum) | ||||
Receptorium histamini H4, abbreviatura HRH4 est receptorium histamini et familiae receptoriorum proteino G copulatorum.
Stimulatio HRH4 chemotaxem mastocytorum atque muitationem formae granulocytorum eosinophilorum contrahit[1]. In testium cellulis Leydigiensibus steroidogenesem receptoriorum H4 ope inhibere videtur[2].
Agonista est Clozapinum, antagonista Pimozidum.
Polymorphismi geni receptorii cancrum contrahere potest.
- ↑ Hofstra C. L., Desai P. J., Thurmond R. L., Fung-Leung W. P. (2003). "Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells". The journal of pharmacology and experimental therapeutics 305 (3): 1212-21
- ↑ Abiuso A. M., Berensztein E., Pagotto R. M.ö, Pereyra E. N., Medina V., Martinel Lamas D. J., Besio Moreno M., Pignataro O. P., Mondillo C. (2014). "H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells". The journal of endocrinology 223 (3): 241-53