ERT2

MAPK3
Estruturas disponíveis PDB Pesquisa Human UniProt: PDBe RCSB Lista de códigos id do PDB 2ZOQ, 4QTB
Identificadores
Nomes alternativos	MAPK3, p44MAPK, ERT2, ERK1
IDs externos	OMIM: 601795 HomoloGene: 55682 GeneCards: MAPK3
Targeted by Drug
ravoxertinib, ulixertinib[1]
Ontologia genética Função molecular • phosphatase binding • ATP binding • protein kinase activity • MAP kinase activity • transferase activity • phosphotyrosine residue binding • scaffold protein binding • GO:0001948, GO:0016582 ligação a proteínas plasmáticas • nucleotide binding • kinase activity • protein serine/threonine kinase activity • MAP kinase kinase activity • identical protein binding Componente celular • citosol • envelope nuclear • focal adhesion • mitocôndria • citoesqueleto • núcleo celular • late endosome • complexo de Golgi • early endosome • pseudópode • cariolinfa • citoplasma • membrana plasmática • caveola • membrane • GO:0009327 complexo macromolecular Processo biológico • caveolin-mediated endocytosis • positive regulation of protein phosphorylation • positive regulation of telomere capping • response to exogenous dsRNA • cardiac neural crest cell development involved in heart development • positive regulation of xenophagy • positive regulation of translation • cellular response to DNA damage stimulus • platelet activation • Fc-epsilon receptor signaling pathway • protein phosphorylation • cellular response to mechanical stimulus • face development • GO:0033129 positive regulation of histone modification • regulation of DNA-binding transcription factor activity • DNA damage induced protein phosphorylation • positive regulation of ERK1 and ERK2 cascade • animal organ morphogenesis • ciclo celular • GO:0097285 apoptose • Fc-gamma receptor signaling pathway involved in phagocytosis • thymus development • ERK1 and ERK2 cascade • negative regulation of apolipoprotein binding • transcription, DNA-templated • cartilage development • GO:0022415 viral process • response to toxic substance • regulation of stress-activated MAPK cascade • fosforilação • outer ear morphogenesis • BMP signaling pathway • response to lipopolysaccharide • thyroid gland development • response to epidermal growth factor • positive regulation of MAP kinase activity • positive regulation of telomerase activity • peptidyl-tyrosine autophosphorylation • nocicepção • positive regulation of cyclase activity • trachea formation • lipopolysaccharide-mediated signaling pathway • GO:0007243 intracellular signal transduction • lung morphogenesis • neural crest cell development • transcription initiation from RNA polymerase I promoter • regulation of early endosome to late endosome transport • positive regulation of telomere maintenance via telomerase • MAPK cascade • positive regulation of histone acetylation • Guia do axônio • interleukin-1-mediated signaling pathway • fibroblast growth factor receptor signaling pathway • GO:0035404 peptidyl-serine phosphorylation • regulation of cellular response to heat • Bergmann glial cell differentiation • regulation of Golgi inheritance • arachidonic acid metabolic process • regulation of cytoskeleton organization • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of phosphatidylinositol 3-kinase signaling • regulation of ossification • GO:1901313 positive regulation of gene expression • positive regulation of macrophage chemotaxis • cellular response to amino acid starvation • GO:0072353 cellular response to reactive oxygen species • stress-activated MAPK cascade • cellular response to cadmium ion • cellular response to dopamine • positive regulation of metallopeptidase activity • regulation of cellular pH • GO:0034622 protein-containing complex assembly • cellular response to tumor necrosis factor • regulação genética • cellular response to organic substance • GO:0010260 envelhecimento • decidualization Sources:Amigo / QuickGO
Padrão de expressão RNA Mais dados de referência de expressão
Ortólogos Espécie Humano Rato Entrez 5595 n/a Ensembl ENSG00000102882 n/a UniProt P27361 n/a RefSeq (mRNA) NM_001040056 NM_001109891 NM_002746 n/a RefSeq (proteína) NP_001035145 NP_001103361 NP_002737 n/a Localização (UCSC) n/a n/a Pesquisa PubMed [2] n/a
Wikidata
Ver/Editar Humano

ERT2, também conhecida como p44MAPK, MAPK3 e ERK1, é uma enzima que em humanos é codificada pelo gene MAPK3.^[3]

Ela é um membro da superfamília de proteína quinase, família de proteína cinase CMGC Ser/Thr, subfamília de MAP quinase. ERT2 é um apelido para o gene, proteína quinase 3 (ativada por mitógeno), em seres humanos.^[4][5] Os pesquisadores fundiram a enzima a ERT2, em seguida ativaram o complexo com um análogo de tamoxifeno, 4-hidroxitamoxifeno, no caso de Cas9, a fim de colocar os controles no sistema CRISPR/Cas9.^[6].