RANKL

RANKL
PDB прорисовано на основе 1s55.
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
Список идентификаторов PDB 3URF
Идентификаторы
Символ	TNFSF11 ; CD254; ODF; OPGL; OPTB2; RANKL; TRANCE; hRANKL2; sOdf
Внешние ID	OMIM: 602642 MGI: 1100089 HomoloGene: 2744 GeneCards: Ген TNFSF11
Генная онтология Функция • cytokine activity • tumor necrosis factor receptor binding • tumor necrosis factor receptor superfamily binding Компонент клетки • extracellular region • extracellular space • cytoplasm • integral component of plasma membrane Биологический процесс • ossification • osteoclast proliferation • monocyte chemotaxis • immune response • activation of JUN kinase activity • organ morphogenesis • cytokine-mediated signaling pathway • osteoclast differentiation • tumor necrosis factor-mediated signaling pathway • mammary gland epithelial cell proliferation • positive regulation of homotypic cell-cell adhesion • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of MAP kinase activity • bone resorption • positive regulation of osteoclast differentiation • positive regulation of bone resorption • positive regulation of transcription from RNA polymerase II promoter • positive regulation of JNK cascade • positive regulation of T cell activation • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity • protein homooligomerization • positive regulation of corticotropin-releasing hormone secretion • positive regulation of protein kinase B signaling • calcium ion homeostasis • mammary gland alveolus development • ERK1 and ERK2 cascade • positive regulation of fever generation by positive regulation of prostaglandin secretion • TNFSF11-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling • positive regulation of intracellular signal transduction Источники: Amigo / QuickGO
Профиль экспрессии РНК
Больше информации
Ортологи
Вид	Человек	Мышь
Entrez	8600	21943
Ensembl	ENSG00000120659	ENSMUSG00000022015
UniProt	O14788	O35235
RefSeq (мРНК)	NM_003701	NM_011613
RefSeq (белок)	NP_003692	NP_035743
Локус (UCSC)	Chr 13: 43.14 – 43.18 Mb	Chr 14: 78.28 – 78.31 Mb
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TNFSF11, или RANKL (от англ. Tumor necrosis factor ligand superfamily member 11; Receptor activator of nuclear factor kappa-B ligand) — мембранный белок, цитокин семейства факторов некроза опухоли. Продукт гена человека TNFSF11. Играет важную роль в метаболизме костной ткани, активируя остеокласты.