Back أسيبوتولول Arabic Acebutolol BS Acebwtolol Welsh Acebutolol German Acebutolol English Acebutolol Spanish اسبوتولول Persian Acébutolol French Asebutolol ID Acebutololo Italian
| |||
| (IUPAC) ime | |||
|---|---|---|---|
| (RS)-N-(3-acetil-4-[2-hidroksi-3-(propan-2-ilamino)propoksi]fenil)butanamid | |||
| Klinički podaci | |||
| Robne marke | Sectral | ||
| AHFS/Drugs.com | Monografija | ||
| MedlinePlus | a687003 | ||
| Identifikatori | |||
| CAS broj | 37517-30-9 | ||
| ATC kod | C07AB04 | ||
| PubChem[1][2] | 1978 | ||
| DrugBank | DB01193 | ||
| ChemSpider[3] | 1901 | ||
| UNII | 67P356D8GH 
| ||
| KEGG[4] | D02338
| ||
| ChEBI | CHEBI:2379
| ||
| ChEMBL[5] | CHEMBL642
| ||
| Hemijski podaci | |||
| Formula | C18H28N2O4 | ||
| Mol. masa | 336,426 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Fizički podaci | |||
| Tačka topljenja | 121 °C (250 °F) | ||
| Farmakokinetički podaci | |||
| Bioraspoloživost | 40% (opseg 35 do 50%) | ||
| Metabolizam | Hepatički | ||
| Poluvreme eliminacije | 3-4 sata (lek) 8-13 sata (aktivni metabolit) | ||
| Izlučivanje | Renalno: 30% Bilijarno: 60% | ||
| Farmakoinformacioni podaci | |||
| Licenca | |||
| Trudnoća | C(AU) B(US) | ||
| Pravni status | ℞ Prescription only | ||
| Način primene | oralno, iv | ||
Acebutolol (Sektral, Prent) je beta blokator za tretman hipertenzije i aritmija.[6][7]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- ↑ Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0.