Agutiju srodni peptid

Aguti protein

Identifikatori
Simbol	Agouti
Pfam	PF05039
Pfam klan	CL0083
InterPro	IPR007733
PROSITE	PDOC60024
SCOP	1hyk
Superfamilija	1hyk
OPM protein	1mr0
Dostupne PDB strukture: Pfam structures PDB RCSB PDB; PDBe PDBsum strukturni pregled

Agutiju srodni peptid (Agutiju srodni protein, AgRP) je neuropeptid koji proizvode AgRP/NPY neuroni u mozgu. Njega jedino sintetišu ćelije koje sadrže NPY, koje su locirane u ventromedijalnom delu arkuatnog nukleusa u hipotalamusu.^[1] AgRP se koizražava sa neuropeptidom Y i doprinosi povećanju apetita i umanjenju metabolizma i utroška energije. On je jedan od najpotentnijih i najdugotrajnijih stimulatora apetita. Kod ljudi, agutiju srodni peptid je kodiran AGRP genom.^[2][3]

1. ↑ Bäckberg M, Madjid N, Ogren SO, Meister B (June 2004). „Down-regulated expression of agouti-related protein (AGRP) mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice”. Brain Res. Mol. Brain Res. 125 (1-2): 129–39. DOI:10.1016/j.molbrainres.2004.03.012. PMID 15193430. 
2. ↑ Shutter JR, Graham M, Kinsey AC, Scully S, Lüthy R, Stark KL (March 1997). „Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice”. Genes Dev. 11 (5): 593–602. DOI:10.1101/gad.11.5.593. PMID 9119224. 
3. ↑ Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS (October 1997). „Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein”. Science 278 (5335): 135–8. DOI:10.1126/science.278.5335.135. PMID 9311920.