Apraklonidin

Apraklonidin
(IUPAC) ime
	2,6-dihloro-N- (4,5-dihidro-1H-imidazol-2-il) benzen-1,4-diamin
Klinički podaci
Robne marke	Iopidine
AHFS/Drugs.com	Monografija
MedlinePlus	a608005
Identifikatori
CAS broj	66711-21-5
ATC kod	S01EA03
PubChem	2216
DrugBank	DB00964
ChemSpider	2130
UNII	843CEN85DI
KEGG	D07461
ChEBI	CHEBI:2788
ChEMBL	CHEMBL647
Hemijski podaci
Formula	C9H10Cl2N4
Mol. masa	245,108 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15) ; Key: IEJXVRYNEISIKR-UHFFFAOYSA-N
Farmakokinetički podaci
Vezivanje za proteine plazme	98,7%
Poluvreme eliminacije	8 sata
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Rx only
Način primene	Ofthalmički rastvor

Apraklonidin (Iopidine) je simpatomimetik koji se koristi u terapiji glaukoma. On je agonist α₂-adrenergičkog receptora i slab agonist alfa-1 adrenergičkog receptora.

Apraklonidin se administrira u koncentraciji od 1% za sprečavanje i tretman povišenog posthirurškog intraokularnog pritiska i 0.5% za kratkotrajnu adjunktivnu terapiju kod pacijenata na maksimalno tolerisanoj medicinskoj terapiji kojima je neohodna dodatna redirekcija intraokularnog pritiska. Jedna kap se obično dodaje jedan sat pre laserske operacije oka i još jedna kap nakon završetka procedure.

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

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Apraklonidin

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