Back ديميكلوسيكلين Arabic ديميكلوسيكلين AZB Demeclocyclin Welsh Demeclocyclin German Demeclocycline English Demeclociclina Spanish دمکلوسایکلین Persian Demeklosykliini Finnish Déméclocycline French Demeklosiklin ID
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| (IUPAC) ime | |||
|---|---|---|---|
| (2E,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 127-33-3 64-73-3 (HCl) | ||
| ATC kod | D06AA01 J01AA01 | ||
| PubChem[1][2] | 5311063 | ||
| DrugBank | APRD00272 | ||
| ChemSpider[3] | 10482117 | ||
| UNII | 5R5W9ICI6O 
| ||
| KEGG[4] | D03680 | ||
| ChEMBL[5] | CHEMBL1591
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| Hemijski podaci | |||
| Formula | C21H21ClN2O8 | ||
| Mol. masa | 464.853 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
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| Farmakokinetički podaci | |||
| Bioraspoloživost | 60–80% | ||
| Vezivanje za proteine plazme | 41–50% | ||
| Metabolizam | Hepatički | ||
| Poluvreme eliminacije | 10–17 časa | ||
| Izlučivanje | Renalno | ||
| Farmakoinformacioni podaci | |||
| Trudnoća | D(US) | ||
| Pravni status | ℞ Prescription only | ||
| Način primene | Oralno | ||
Demeklociklin (Deklomicin, Deklostatin i Ledermicin) je tetraciklinski antibiotik. On je izolovan iz aktinobakterijske vrste Streptomyces aureofaciens.[6]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 izd.). New York: McGraw-Hill. ISBN 0-07-142280-3.