Back فيسوستيغمين Arabic فیزوستیقمین AZB Fisostigmina Catalan Fysostigmin Czech Ffysostigmin Welsh Physostigmin German Physostigmine English Fisostigmina Spanish فیزوستیگمین Persian Fysostigmiini Finnish
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| (IUPAC) ime | |||
|---|---|---|---|
| (3aR,8aS)-1,3a,8-Trimetil-1H,2H,3H,3aH,8H,8aH-pirolo[2,3-b]indol-5-il N-metilkarbamat | |||
| Klinički podaci | |||
| Robne marke | Antilirium | ||
| AHFS/Drugs.com | Monografija | ||
| Identifikatori | |||
| CAS broj | 57-47-6 | ||
| ATC kod | S01EB05 V03AB19 | ||
| PubChem[1][2] | 5983 | ||
| DrugBank | DB00981 | ||
| ChemSpider[3] | 5763 | ||
| UNII | 9U1VM840SP 
| ||
| KEGG[4] | D00196
| ||
| ChEBI | CHEBI:27953
| ||
| ChEMBL[5] | CHEMBL94
| ||
| Hemijski podaci | |||
| Formula | C15H21N3O2 | ||
| Mol. masa | 275,346 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakokinetički podaci | |||
| Metabolizam | Glavni metabolit: Eserolin | ||
| Farmakoinformacioni podaci | |||
| Trudnoća | C(US) | ||
| Pravni status | ℞-only (SAD) | ||
| Način primene | intravenonozno, intramuskularno, ofthalmički | ||
Fizostigmin (eserin) je parasimpatomimetski alkaloid. On je reverzibilni inhibitor holinesteraze.
Ova supstanca je sintetisana 1935. Dostupna je pod imenima: Antilirium, Isopto Eserine, Eserin salicilat i Eserin sulfat.
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.