Ketazocin

Ketazocin
(IUPAC) ime
	(2S,6R,11R)-3-(cyclopropylmethyl)-8-hydroxy-6,11-dimethyl-3,4,5,6-tetrahydro-2,6-methano-3-benzazocin-1(2H)-one
Klinički podaci
Identifikatori
CAS broj	36292-69-0
ATC kod	nije dodeljen
PubChem	3054741
ChemSpider	2316328
KEGG	D04649
Hemijski podaci
Formula	C18H23NO2
Mol. masa	285.38 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C18H23NO2/c1-11-16-17(21)14-6-5-13(20)9-15(14)18(11,2)7-8-19(16)10-12-3-4-12/h5-6,9,11-12,16,20H,3-4,7-8,10H2,1-2H3/t11-,16-,18+/m0/s1 ; Key: HQBZLVPZOGIAIQ-SDDDUWNISA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	?
Način primene	Oralno

Ketazocin (INN), takođe poznat kao ketociklazocin, je benzomorfanski derivativ koji se koristi u istraživanjima opioidnih receptora. Ketociklazocin je egzogeni opioid koji se vezuje za kapa opioidni receptor.^[5]

Aktivacija ovog receptora uzrokuje umanjenje senzacije bola i povećanje pospanosti, ali takođe može da bude uzrok psiholoških simptoma kao što su osećanje nelagodnosti, paranoje, i halucinacija. On može da dovede do povišenja produkcije urina, zato što inhibira oslobađanje vazopresina. (Vazopresin je endogena supstanca koja pomaže u regulaciji fluidnog i elektrolitnog balansa u telu i umanjuje količinu vode oslobođene u urin.)

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Leander JD (1982). „Effects of ketazocine, ethylketazocine and phenazocine on schedule-controlled behavior: antagonism by naloxone”. Neuropharmacology 21 (9): 923-8. PMID 6128693.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Leander JD (1982). „Effects of ketazocine, ethylketazocine and phenazocine on schedule-controlled behavior: antagonism by naloxone”. Neuropharmacology 21 (9): 923-8. PMID 6128693.

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Ketazocin

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