Melanokortinski receptor

Melanokortin receptori su članovi rodopsin familije 7-transmembranskih G protein-spregnutih receptora.

Pet članova melanokortin receptorskog sistema je poznato^[1] svaki od kojih ima osobenu specifičnost za melanokortine,^[2][3][4]

• MC1R. MC1R je asociran sa genetikom pigmentacije.
• MC2R. MC2R je takođe poznat kao ACTH receptor ili kortikotropin receptor.
• MC3R. MC3R
• MC4R. MC4R defekti su uzrok autozomalno dominantne gojaznosti, koja sačinjava 6% svih slučajeva rane gojaznosti.^[5]
• MC5R. MC5R

Ovi receptori su inhibirani endogenim inverznim agonistima agouti signalni peptid i agutiju srodni peptid,^[6] i aktivirani sintetičkim (ie: afamelanotid) i endogenim agonistima melanocit-stimulišući hormonima.^[7]

1. ↑ „Melanocortins and the Melanocortin Receptor”. Arhivirano iz originala na datum 2007-04-11. Pristupljeno 2014-04-21. 
2. ↑ Voisey J, Carroll L, van Daal A (October 2003). „Melanocortins and their receptors and antagonists”. Current Drug Targets 4 (7): 586–97. DOI:10.2174/1389450033490858. PMID 14535656. 
3. ↑ Hadley ME, Dorr RT (April 2006). „Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization”. Peptides 27 (4): 921–30. DOI:10.1016/j.peptides.2005.01.029. PMID 16412534. 
4. ↑ Dores RM (April 2009). „Adrenocorticotropic hormone, melanocyte-stimulating hormone, and the melanocortin receptors: revisiting the work of Robert Schwyzer: a thirty-year retrospective”. Annals of the New York Academy of Sciences 1163: 93–100. DOI:10.1111/j.1749-6632.2009.04434.x. PMID 19456331. 
5. ↑ Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S (2003). „Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene”. The New England Journal of Medicine 348 (12): 1085–95. DOI:10.1056/NEJMoa022050. PMID 12646665. 
6. ↑ Chai B, Pogozheva I, Lai Y, Li J, Neubig R, Mosberg H, Gantz I (2005). „Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors”. Biochemistry 44 (9): 3418–31. DOI:10.1021/bi0478704. PMID 15736952. 
7. ↑ Pogozheva I, Chai B, Lomize A, Fong T, Weinberg D, Nargund R, Mulholland M, Gantz I, Mosberg H (2005). „Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists”. Biochemistry 44 (34): 11329–41. DOI:10.1021/bi0501840. PMC 2532597. PMID 16114870.