Back براميبيكسول Arabic پرامیپکسول AZB Pramipecsol Welsh Pramipexol German Πραμιπεξόλη Greek Pramipexole English Pramipexol Spanish Pramipexol Basque پرامیپکسول Persian Pramipeksoli Finnish
| |||
| (IUPAC) ime | |||
|---|---|---|---|
| (S)-N6-propyl-4,5,6,7-tetrahidro-1,3-benzotiazol-2,6-diamin | |||
| Klinički podaci | |||
| Robne marke | Mirapex | ||
| AHFS/Drugs.com | Monografija | ||
| MedlinePlus | a697029 | ||
| Identifikatori | |||
| CAS broj | 104632-26-0 | ||
| ATC kod | N04BC05 | ||
| PubChem[1][2] | 119570 | ||
| DrugBank | APRD00156 | ||
| ChemSpider[3] | 106770 | ||
| UNII | 83619PEU5T 
| ||
| KEGG[4] | D05575
| ||
| ChEBI | CHEBI:8356
| ||
| ChEMBL[5] | CHEMBL301265
| ||
| Hemijski podaci | |||
| Formula | C10H17N3S | ||
| Mol. masa | 211,324 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakokinetički podaci | |||
| Bioraspoloživost | >90% | ||
| Vezivanje za proteine plazme | 15% | ||
| Poluvreme eliminacije | 8-12 sata | ||
| Izlučivanje | Urin (90%), Fekalije (2%) | ||
| Farmakoinformacioni podaci | |||
| Trudnoća | B3(AU) C(US) | ||
| Pravni status | ℞ Prescription only | ||
| Način primene | Oralno | ||
Pramipeksol (Mirapeks, Mirapeksin, Sifrol) je dopaminski agonist koji se koristi za lečenje rane faze Parkinsonove bolesti i sindroma nemirnih nogu.[6] Poznato je da se on koristi i za lečenje jake glavobolje i za neutralisanje psihičkih problema izazvanih impotencijom, koju doživljavaju neki od korisnika antidepresanata ili selektivnih inhibitora preuzimanja serotonina, mada pramipeksol zvanično nije odobren za lečenje tih poremećaja.[7]
Pramipeksol je u jednoj pilot placebo kontrolisanoj studiji sprovedenoj radi potvrde koncepta u manično-depresivnoj psihozi pokazao da ima snažno dejstvo.[8] On se takođe ispituje za primenu u lečenju kliničke derpesije i fibromialgije.[9][10][11]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ National Prescribing Service (2009). "Pramipexole for Parkinson's Disease". Medicines Update. Available at http://www.nps.org.au/consumers/publications/medicine_update/issues/Pramipexole_for_Parkinsons_disease
- ↑ DeBattista C, Solvason HB, Breen JA, Schatzberg AF. (2000). „Pramipexole augmentation of a selective serotonin reuptake inhibitor in the treatment of depression.”. J Clin Psychopharmacol. 20 (2): 274–275. DOI:10.1097/00004714-200004000-00029. PMID 10770475.
- ↑ Zarate CA, Payne JL, Singh J, et al. (July 2004). „Pramipexole for bipolar II depression: a placebo-controlled proof of concept study”. Biol. Psychiatry 56 (1): 54–60. DOI:10.1016/j.biopsych.2004.03.013. PMID 15219473.
- ↑ Lattanzi L, Dell'Osso L, Cassano P, Pini S, Rucci P, Houck PR, Gemignani A, Battistini G, Bassi A, Abelli M, Cassano GB. (2002). „Pramipexole in treatment-resistant depression: a 16-week naturalistic study.”. Bipolar Disord. 4 (5): 307–314. DOI:10.1034/j.1399-5618.2002.01171.x. PMID 12479663.
- ↑ Cassano P, Lattanzi L, Soldani F, Navari S, Battistini G, Gemignani A, Cassano GB. (2004). „Pramipexole in treatment-resistant depression: an extended follow-up.”. Depression and Anxiety 20 (3): 131–138. DOI:10.1002/da.20038. PMID 15549689.
- ↑ Holman AJ, Myers RR. (2005). „A randomized, double-blind, placebo-controlled trial of pramipexole, a dopamine agonist, in patients with fibromyalgia receiving concomitant medications.”. Arthritis Rheum. 52 (8): 2495–2505. DOI:10.1002/art.21191. PMID 16052595.