Back TYMS Welsh Thymidylat-Synthase German Thymidylate synthase English Timidilato sintasa Spanish Thymidylate synthase French Timidilato sintasi Italian Syntaza tymidylanowa Polish Timidilato sintetase Portuguese Timidilat sintaza Serbian TYMS Ukrainian
| Timidilat sintaza | |||||||||
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| Timidilat sintaza dimer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.1.1.45 | ||||||||
| CAS broj | 9031-61-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Timidilat sintaza (EC 2.1.1.45, dTMP sintaza, timidilatna sintetaza, metilintetrahidrofolat:dUMP C-metiltransferaza, TMP sintetaza) je enzim sa sistematskim imenom 5,10-metilintetrahidrofolat:dUMP C-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5,10-metilintetrahidrofolat + dUMP dihidrofolat + dTMP
- ↑ Blakley, R.L. (1963). „The biosynthesis of thymidylic acid. IV. Further studies on thymidylate synthase”. J. Biol. Chem. 238: 2113-2118.
- ↑ Lockshin, A., Moran, R.G. and Danenberg, P.V. (1979). „Thymidylate synthetase purified to homogeneity from human leukemic cells”. Proc. Natl. Acad. Sci. USA 76: 750-754. PMID 34155.
- ↑ Slavik, K. and Slavikova, V. (1980). „Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography”. Methods Enzymol. 66: 709-723. PMID 6990200.
- ↑ Wahba, A.J. and Friedkin, M. (1962). „The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli”. J. Biol. Chem. 237: 3794-3801. PMID 13998281.