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A man is an adult male human. He is the opposite of a woman. People use the word "man" (one man, two or more men) to talk about gender. Manhood is the period in a male's life after he changes from a boy. A boy is a male child; a female child is called a girl. After boys reach maturity, they can be called a man.
Like most other male mammals, a man inherits an X chromosome from his mother and a Y chromosome from his father. What makes someone a man is not agreed on globally.