Fluocinolon acetonid

Fluocinolon acetonid
Klinički podaci
Prodajno ime	Coriphate, Derma-smoothe/fs, Dermalar, Flucinar
Drugs.com	acetonide.html Monografija
Način primene	topikalno, intraokularno
Farmakokinetički podaci
Poluvreme eliminacije	1,3-1,7 h
Izlučivanje	Renalno
Identifikatori
CAS broj	67-73-2
ATC kod	C05AA10 (WHO), S02BA08
PubChem	CID 6215
DrugBank	DB00591
ChemSpider	5980
ChEMBL	CHEMBL989
Hemijski podaci
Formula	C24H30F2O6
Molarna masa	452,488
	SMILES [H][C@@]12C[C@@]3([H])[C@]4([H])C[C@]([H])(F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(=O)CO; ;
	InChI InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1 ; Key:FEBLZLNTKCEFIT-VSXGLTOVSA-N ;
Fizički podaci
Tačka topljenja	265—266 °C (509—511 °F)

Fluocinolon acetonid je organsko jedinjenje, koje sadrži 24 atoma ugljenika i ima molekulsku masu od 452,488 Da.^[1]^[2]^[3]^[4]^[5]

^ Goldstein DA, Godfrey DG, Hall A, Callanan DG, Jaffe GJ, Pearson PA, Usner DW, Comstock TL: Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants. Arch Ophthalmol. 2007 Nov;125(11):1478-85. Epub 2007 Oct 8. PMID 17923537
^ Brumm MV, Nguyen QD: Fluocinolone acetonide intravitreal sustained release device--a new addition to the armamentarium of uveitic management. Int J Nanomedicine. 2007;2(1):55-64. PMID 17722513
^ Jaffe GJ, Yang CH, Guo H, Denny JP, Lima C, Ashton P: Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device. Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3569-75. PMID 11006254
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.