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| Heterotrimerni G-protein | |||||||||
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| Identifikatori | |||||||||
| EC broj | 3.6.5.1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Heterotrimerni G proteini (EC 3.6.5.1, Heterotrimeric G-protein GTPase) su za membranu vezani G proteini.[1][2][3][4] Oni se ponekad nazivaju "veliki" G proteini. Ovi proteini su aktivirani G protein-spregnutim receptorima. Oni se sastoje od alfa (α), beta (β) i gama (γ) podjedinica[5]. Dve zadnje se nazivaju beta-gama kompleks.
- ^ Neer, E.J. (1995). „Heterotrimeric G proteins: organizers of transmembrane signals”. Cell. 80: 249—259. PMID 7834744.
- ^ Sprang, S.R. (1997). „G protein mechanisms: insights from structural analysis”. Annu. Rev. Biochem. 66: 639—678. PMID 9242920.
- ^ Bondarenko, V.A., Deasi, M., Dua, S., Yamazaki, M., Amin, R.H., Yousif, K.K., Kinumi, T., Ohashi, M., Komori, N., Matsumoto, H., Jackson, K.W., Hayashi, F., Usukura, J., Lipikin, V.M. and Yamazaki, A. (1997). „Residues within the polycationic region of cGMP phosphodiesterase γ subunit crucial for the interaction with transducin α subunit. Identification by endogenous ADP-ribosylation and site-directed mutagenesis”. J. Biol. Chem. 272: 15856—15864. PMID 9188484.
- ^ Ming, D., Ruiz-Avila, L. and Margolskee, R.F. (1998). „Characterization and solubilization of bitter-responsive receptors that couple to gustducin”. Proc. Natl. Acad. Sci. USA. 95: 8933—8938. PMID 9671782.
- ^ Hurowitz EH, Melnyk JM, Chen YJ, Kouros-Mehr H, Simon MI, Shizuya H (2000). „Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes”. DNA Res. 7 (2): 111—20. PMID 10819326. doi:10.1093/dnares/7.2.111.