Back KiSS1-Rezeptor German KiSS1-derived peptide receptor English קולטן KiSS1 HE KISS1R Serbo-Croatian KISS1R Ukrainian
| KISS1 receptor | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | KISS1R; AXOR12; GPR54; HOT7T175 | ||||||||||
| Vanjski ID | OMIM: 604161 MGI: 2148793 HomoloGene: 11411 IUPHAR: KiSS1 GeneCards: KISS1R Gene | ||||||||||
| |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 84634 | 114229 | |||||||||
| Ensembl | ENSG00000116014 | ENSMUSG00000035773 | |||||||||
| UniProt | Q969F8 | Q91V45 | |||||||||
| RefSeq (mRNA) | NM_032551 | NM_053244 | |||||||||
| RefSeq (protein) | NP_115940 | NP_444474 | |||||||||
| Lokacija (UCSC) |
Chr 19: 0.87 - 0.87 Mb |
Chr 10: 79.32 - 79.33 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
KiSS1-izvedeni peptidni receptor (takođe poznat kao KISS1R, GPR54 ili Kispeptinski receptor) je G protein-spregnuti receptor[1] koji vezuje peptidni hormon kispeptin (metastin).[2][3][4] Kispeptin je kodiran genom supresora metastaze KISS1, koji je izražen u raznim endokrinim i gonadnim tkivima.[5] Aktivacija kispeptinskog receptora je vezana sa kaskadom fosfolipaze C i inozitol trisfosfata u ćelija.[6]
- ^ Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O'Dowd BF (1999). „Discovery of a receptor related to the galanin receptors”. FEBS Lett. 446 (1): 103—7. PMID 10100623. doi:10.1016/S0014-5793(99)00009-5.
- ^ Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M (2001). „Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor”. Nature. 411 (6837): 613—7. PMID 11385580. doi:10.1038/35079135.
- ^ Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC (2001). „AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1”. J. Biol. Chem. 276 (31): 28969—75. PMID 11387329. doi:10.1074/jbc.M102743200.
- ^ Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M (2001). „The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54”. J. Biol. Chem. 276 (37): 34631—6. PMID 11457843. doi:10.1074/jbc.M104847200.
- ^ Richard N, Corvaisier S, Camacho E, Kottler ML (2009). „KiSS-1 and GPR54 at the pituitary level: overview and recent insights”. Peptides. 30 (1): 123—9. PMID 18948153. doi:10.1016/j.peptides.2008.09.015.
- ^ Liu X, Lee K, Herbison AE (2008). „Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels”. Endocrinology. 149 (9): 4605—14. PMID 18483150. doi:10.1210/en.2008-0321.