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Alternatives to animal testing are the development and implementation of test methods that avoid the use of live animals. There is widespread agreement that a reduction in the number of animals used and the refinement of testing to reduce suffering should be important goals for the industries involved.[1] Two major alternatives to in vivo animal testing are in vitro cell culture techniques and in silico computer simulation; however, some claim they are not true alternatives because simulations use data from prior animal experiments and cell cultures often require animal derived products, such as serum or cells. Others say that they cannot replace animals completely as they are unlikely to ever provide enough information about the complex interactions of living systems.[2]
Other alternatives include the use of humans for skin irritancy tests and donated human blood for pyrogenicity studies. Another alternative is microdosing, in which the basic behaviour of drugs is assessed using human volunteers receiving doses well below those expected to produce whole-body effects.[3] While microdosing produces important information about pharmacokinetics and pharmacodynamics, it does not reveal information about toxicity or toxicology.[4] Furthermore, it was observed by the Fund for the Replacement of Animals in Medical Experiments that despite the use of microdosing, "animal studies will still be required".[5]
Guiding principles for more ethical use of animals in testing are the Three Rs (3Rs) first described by Russell and Burch in 1959.[6] These principles are now followed in many testing establishments worldwide.
- Replacement refers to the preferred use of non-animal methods over animal methods whenever it is possible to achieve the same scientific aim.
- Reduction refers to methods that enable researchers to obtain comparable levels of information from fewer animals, or to obtain more information from the same number of animals.
- Refinement refers to methods that alleviate or minimize potential pain, suffering, or distress, and enhance animal welfare for the animals used.
- ^ R E Hester R M Harrison et al. Alternatives To Animal Testing (Issues in Environmental Science and Technology) Royal Society of Chemistry; 1 edition (June 7, 2006) ISBN 978-0-85404-211-1
- ^ Lipinski, Christopher; Hopkins, A (16 December 2004). "Navigating chemical space for biology and medicine". Nature. 432 (7019): 855–61. Bibcode:2004Natur.432..855L. doi:10.1038/nature03193. PMID 15602551. S2CID 4416216.
- ^ Malcolm Rowland (February 2006). "Microdosing and the 3Rs". National Center for the Replacement, Refinement, and Reduction of Animals in Research ( NC3Rs ). Archived from the original on 28 September 2007. Retrieved 22 September 2007.
- ^ "Alternatives?". Speaking of Research. 31 July 2009. Retrieved 26 February 2014.
- ^ FRAME (2005). "Human microdosing reduces the number of animals required for pre-clinical pharmaceutical research". Alternatives to Laboratory Animals. 33 (439).
- ^ Russell, W.M.S. and Burch, R.L., (1959). The Principles of Humane Experimental Technique, Methuen, London. ISBN 0-900767-78-2 [1] Archived 2011-09-27 at the Wayback Machine Digital text Archived 2022-12-01 at the Wayback Machine available for free on the website of the Center for Alternatives to Animal Testing.