Back أركيدونات 5-أكسيجيناز شحمية Arabic ALOX5 BS ALOX5 Welsh Arachidonat-5-Lipoxygenase German 5-lipooxigenasa Spanish Arachidonato 5-lipossigenasi Italian アラキドン酸-5-リポキシゲナーゼ Japanese Arahidonat 5-lipoksigenaza Serbo-Croatian Arahidonat 5-lipoksigenaza Serbian ALOX5 Ukrainian
| arachidonate 5-lipoxygenase | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | 5-lipoxygenase | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | GeneCards: [1]; OMA:- orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| arachidonate 5-lipoxygenase | |||||||||
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| Identifiers | |||||||||
| EC no. | 1.13.11.34 | ||||||||
| CAS no. | 80619-02-9[permanent dead link] | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans is encoded by the ALOX5 gene.[1] Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms essential fatty acids (EFA) substrates into leukotrienes as well as a wide range of other biologically active products. ALOX5 is a current target for pharmaceutical intervention in a number of diseases.
- ^ Funk CD, Hoshiko S, Matsumoto T, Rdmark O, Samuelsson B (Apr 1989). "Characterization of the human 5-lipoxygenase gene". Proceedings of the National Academy of Sciences of the United States of America. 86 (8): 2587–2591. Bibcode:1989PNAS...86.2587F. doi:10.1073/pnas.86.8.2587. PMC 286962. PMID 2565035.